Exploring geometry and chirality in life by probing the sphinx tile. Why is the heart…
Browsing: Structural Biology
Structural biology is a subfield of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules like proteins, nucleic acids, and their complexes. It aims to provide a detailed understanding of the molecular architecture of these macromolecules and how alterations in their structures affect their function. Techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM) are commonly used to determine the positions of atoms within a molecule in three-dimensional space. Insights gained from structural biology are crucial for elucidating the mechanisms of biological processes and for designing drugs that can interact with proteins and other targets at the molecular level. This field has contributed significantly to the development of new therapeutics, understanding disease mechanisms, and the design of novel enzymes for industrial applications.
Scientists at Scripps Research have developed atomic-level structural models of enzymes linked to autoimmune and…
A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat,…
A significant study identifies a genetic variant in the SYCE2 gene that heightens the risk…
New crystallography experiments using high pressure and heat to reveal how proteins change shape could…
Neurons communicate through chemical signals known as neurotransmitters. Researchers at St. Jude Children’s Research Hospital,…
University of Missouri researchers’ conceptual design of a nanomaterial could potentially pave the way for…
The study identifies areas impacted by hazardous genetic alterations. Scientists at Ohio State University have…
Scientists at the Vienna BioCenter and UNC School of Medicine revealed the intercellular choreography that…
Detailed 3D modeling aided Rice scientists in enhancing the system’s precision. Small and precise: These…
Using ultrafast physics in structural biology has unveiled the intricate dance of molecular ‘coherence’ in…
Researchers at Cold Spring Harbor Laboratory have generated detailed images of a neuronal channel known…
Exciting new findings shed light on the interaction between the protein calmodulin and an ion…
Research indicates that certain neural cell circuits responsible for color vision are exclusive to humans.…
Extremely long tail provides a window into how bacteria-infecting viruses assemble. A recent study in…
Tokyo Tech developed a new cell-free protein crystallization (CFPC) method that includes direct protein crystallization…
Chiral molecules exist in two forms known as enantiomers, which are mirror images of each…
Combination of nucleic acid nanotechnology and cryo-EM gives unprecedented insights into the structures of large…