Inflammation News - SciTechDaily

New Study Unravels the Mystery of COVID’s Worst Pediatric Complication

University of California San Francisco — Thu, 15 Aug 2024 22:58:46 +0000

A study identified how children’s immune systems trigger MIS-C by mistaking a COVID-19 protein for a similar human protein, leading to severe autoimmune responses. This finding provides new perspectives on treating autoimmune diseases linked to viral infections. Research uncovers a mechanism behind multisystem inflammatory syndrome in children (MIS-C). During the early stages of the COVID-19 [...]

Mast Cells Trap Living Neutrophils During Allergic Reactions – “We Could Hardly Believe Our Eyes”

Max Planck Institute of Immunobiology and Epigenetics — Fri, 02 Aug 2024 15:00:35 +0000

Researchers have discovered a surprising interaction between mast cells and neutrophils in allergic reactions, using specialized microscopy. Mast cells can trap and engulf neutrophils, creating a cell-in-cell structure known as “mast cell intracellular trap” (MIT). This interaction boosts mast cell function and could lead to new approaches for treating allergies and inflammatory diseases. The findings [...]

Young Adult Health Habits Linked to Midlife Cognitive Decline

University of California - San Francisco — Fri, 02 Aug 2024 10:08:34 +0000

A UCSF study reveals that higher inflammation levels in young adults are associated with poorer cognitive performance in midlife, underscoring the importance of lifestyle choices in reducing inflammation and preventing cognitive decline. Higher levels of inflammation in young adults, associated with factors like obesity, physical inactivity, chronic illness, stress, and smoking, are linked to decreased [...]

Macrophage Mayhem Unlocks Clues to Rare Neurodegenerative Condition

The Hospital for Sick Children — Fri, 12 Jul 2024 09:00:02 +0000

New research indicates that inflammation in macrophages caused by lysosomal dysfunction contributes to severe symptoms in lysosomal storage diseases. Targeting specific pathways in these cells may offer new therapeutic options for these genetic conditions. Inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions [...]

New Immune System Defense Pathway Discovered

University Hospital Bonn — Thu, 11 Jul 2024 10:21:52 +0000

Researchers in Bonn have decoded the interaction between monocytes and platelets in human blood. Monocytes, a unique type of white blood cell, release cytokines as inflammatory signals essential for a proper immune response. Researchers at University Hospital Bonn (UKB) and the University of Bonn have discovered that platelets, also called thrombocytes, interact with monocytes, enhancing [...]

New Study Links Gut Vitamin B Deficiency to Parkinson’s Disease

Nagoya University — Thu, 04 Jul 2024 16:25:19 +0000

Nagoya University researchers found that deficiencies in gut bacteria genes for vitamins B2 and B7 are linked to Parkinson’s disease, suggesting that B vitamin supplementation could be a potential treatment. A study conducted by the Nagoya University Graduate School of Medicine in Japan has discovered a connection between gut microbiota and Parkinson’s disease (PD). The [...]

Overturning Traditional Beliefs – Cambridge Scientists Have Discovered “New Rules of the Immune System”

University of Cambridge — Sat, 22 Jun 2024 08:26:26 +0000

Cambridge researchers have discovered that regulatory T cells traverse the body to repair tissue, opening avenues for targeted treatments in various diseases. Researchers at the University of Cambridge have found that regulatory T cells, a kind of white blood cell, form a single, large group that continuously circulates throughout the body to seek out and [...]

Previously Unknown Immune System Link Uncovered – Findings Could Lead to New Cancer Treatments

Weill Cornell Medicine — Mon, 17 Jun 2024 11:49:11 +0000

Weill Cornell scientists discovered a crucial link between two immune pathways involving IL-23 and CTLA-4, impacting the understanding and treatment of inflammatory bowel diseases and informing cancer immunotherapy strategies. Scientists at Weill Cornell Medicine have uncovered a previously unknown connection between two key pathways that regulate the immune system in mammals. This discovery significantly enhances [...]

Beyond Pain Relief: Scientists Discover New Benefit of Aspirin

American Academy of Sleep Medicine — Tue, 11 Jun 2024 20:51:35 +0000

Research reveals that low-dose aspirin reduces inflammation caused by lack of sleep. New research has found that low doses of acetylsalicylic acid, commonly known as aspirin, can reduce inflammatory reactions caused by restricted sleep. The findings indicate that, when compared to a placebo, taking a low dose of aspirin preemptively during periods of sleep deprivation [...]

Could Maternal Immune Responses Trigger Neurodevelopmental Disorders Like Autism?

The Company of Biologists — Wed, 22 May 2024 14:00:19 +0000

Harvard researchers have found that the maternal immune response to viral infections in pregnant mice can be detected by microglia in the embryo’s brain, altering gene regulation in a way that persists into juvenile stages. This discovery could help explain the origins of neurodevelopmental disorders like autism and offer new avenues for therapeutic intervention. No [...]

Researchers Identify Potential Target for Treating Inner-Ear Bone Erosion

Osaka University — Tue, 07 May 2024 17:06:01 +0000

Researchers show that the possible cause of local bone erosion in cholesteatomas are fibroblasts from the bone that express a protein called activin A. Chronic inflammation of the middle ear can cause several problems and complications that can affect a person’s hearing and balance. One such problem is the formation of a cholesteatoma, which is [...]

Depression and Heart Disease: Surprising Genetic Ties Uncovered

Vanderbilt University Medical Center — Mon, 15 Apr 2024 17:28:47 +0000

Research reveals that treating depression and heart disease together could reduce the risk of heart muscle disease. Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital have found. Their report, [...]

“Unheard of in Structural Biology” – New Research Unveils Enzymatic Keys to Immune System Regulation

Scripps Research Institute — Sat, 06 Apr 2024 08:36:35 +0000

Scientists at Scripps Research have developed atomic-level structural models of enzymes linked to autoimmune and inflammatory conditions, such as lupus and Alzheimer’s disease. When nucleic acids, such as DNA or RNA, accumulate in a cell’s cytoplasm, they trigger an alert to the immune system. Under normal circumstances, enzymes are tasked with clearing out these nucleic [...]

Unlocking the Secret Pathway to Slow Aging and Neurodegeneration

EPFL — Sun, 10 Mar 2024 12:33:16 +0000

Inhibiting the STING protein in aged mice leads to decreased inflammation and improved memory and physical function, highlighting a promising approach to mitigating aging-related challenges. As we age, our bodies undergo various changes that can impact our overall health and make us more susceptible to diseases. One common factor in the aging process is low-grade [...]

Improved Performance and Recovery – Scientists Discover New Exercise Benefits of Ginseng

Universitat Oberta de Catalunya (UOC) — Sun, 10 Mar 2024 05:02:06 +0000

A review of 700 studies indicates that incorporating ginseng into one’s diet as a supplement may aid in physical recovery post-exercise, improve performance, and reduce the risk of injuries. Ginseng is one of the most popular food supplements in the world. It is made out of various plants and herbs and is thought to provide [...]

Cambridge Scientists Uncover New Way in Which Fasting Helps Reduce Inflammation

University of Cambridge — Tue, 13 Feb 2024 00:11:42 +0000

Scientists at Cambridge may have uncovered a novel mechanism by which fasting can reduce inflammation – a potentially harmful consequence of the immune system’s activity that is at the root of several chronic illnesses. In research published in Cell Reports, the team describes how fasting raises levels of a chemical in the blood known as [...]

Mitochondrial Stress: Faulty DNA Disposal System Ignites Inflammatory Pathways

Salk Institute — Thu, 08 Feb 2024 10:00:46 +0000

Salk scientists outline mouse cell inflammation pathway from mitochondrial stress to leaking endosomes to immune system initiation, revealing new potential therapeutic targets to reduce inflammation in aging and disease. Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that [...]

Neck Inflammation: The Hidden Culprit Behind Common Headaches

Radiological Society of North America — Sat, 27 Jan 2024 17:51:38 +0000

Researchers presenting at the annual meeting of the Radiological Society of North America (RSNA) have discovered objective evidence showing the involvement of neck muscles in primary headaches. This breakthrough could pave the way for more effective treatments. The distinct underlying causes of primary headaches are still not fully understood. The most common primary headaches are [...]

Harvard’s Startling Discovery: Perceived Time Affects Healing Rate

Harvard University — Sun, 14 Jan 2024 11:49:09 +0000

A Harvard study demonstrates that perceived time can accelerate or slow down physical healing, suggesting a strong mind-body connection in health. Perceived time has a significant impact on the actual time it takes to heal physical wounds, according to new research by Harvard psychologists Peter Aungle and Ellen Langer. Their study, published last month in [...]

A New Era in Pain Management: A Novel Non-Steroidal Anti-Inflammatory

Universitat Politècnica de València — Fri, 12 Jan 2024 21:46:09 +0000

AG5 inhibits the cytokine storm similarly to corticosteroids, but unlike them, it adequately preserves innate immunity. Early in the COVID-19 pandemic, clinical trials with hospitalized patients revealed that corticosteroids, such as dexamethasone, decreased death rates. However, their use at the onset of COVID-19 symptoms proved detrimental. This was attributed to the suppression of the body’s [...]

Unlocking the Genetic Vault: A Key Discovery in Breast Cancer Battle

University of North Carolina Health Care — Wed, 10 Jan 2024 16:00:35 +0000

UNC researchers have discovered how cancer cells escape immune detection by deactivating the cGAS-STING pathway, offering new avenues for cancer treatment. Every time a cancer cell divides, it sustains damage to its own DNA molecules. Researchers, including Gaorav Gupta, MD, PhD, associate professor in the Department of Radiation Oncology at the UNC School of Medicine, [...]

Peptide Power Unleashed: Revolutionizing Inflammation Monitoring

Institute of Physical Chemistry of the Polish Academy of Sciences — Tue, 12 Dec 2023 19:52:24 +0000

Innovative research in CRP peptide-binding offers a new, effective method for monitoring and diagnosing inflammation, enhancing personalized medicine and drug development. Current medical diagnostics is a far cry from the disease’s recognition in the last century. Based on the blood tests, it is possible to detect rare genetic diseases, recognize cancer, or determine the inflammation [...]

Coconut Oil’s Dark Side: New Study Reveals Long-Term Health Risks

São Paulo Research Foundation — Mon, 11 Dec 2023 22:19:44 +0000

In experiments with mice, scientists at the State University of Campinas observed changes in eating patterns, weight growth, signs of anxiety, and heightened inflammation in the brain, fat tissue, and liver. An article published in the Journal of Functional Foods reports on a research study where mice, after being administered an oral supplement of extra-virgin [...]

Scientists Have Discovered Connections Between Neuroinflammation and Alzheimer’s Disease

Brigham and Women's Hospital — Thu, 30 Nov 2023 12:30:37 +0000

A research study conducted by Brigham researchers has uncovered the way in which genetic alterations in specific brain cell types may play a role in the inflammation observed in Alzheimer’s disease. Microglia, immune-regulating cells in the brain, are known to be involved in the development of Alzheimer’s disease (AD). Researchers from Brigham and Women’s Hospital, [...]