Researchers from the University of Liège have released a guide to help better understand and utilize the new reaction space associated with superheated conditions.
Micro/mesofluidic technologies from the University of Liège are transforming chemical synthesis by enabling faster and more efficient reactions. Despite challenges with longer reaction times, innovations like superheated flow technology offer solutions by significantly speeding up reactions, enhancing both productivity and sustainability.
Research initiatives at the University of Liège’s Center for Integrated Technology and Organic Synthesis in Belgium highlight the vast potential of micro/mesofluidic technologies for opening up new areas of chemical reactions. These technologies enable the condensation of process timescales and spaces, broadening the possibilities for enhanced productivity and the discovery of novel reaction pathways. The guide detailing these advancements was recently published in the journal Accounts of Chemical Research.
Continuous flow technology and micro/mesofluidic reactors show great promise for reshaping traditional routes toward chemical manufacturing but still face challenges. Flow technology operates within a very different space- and timeframe compared to conventional process technologies. As discussed in a previous article, the timeframe for a reaction is a critical parameter to ensure viable flow processes at a large scale. While batch processes comfortably accommodate slow reactions over extended timeframes (minutes to days), flow reactors are typically designed for much shorter reaction times (ideally less than one minute, but can reasonably handle reactions up to about 15 minutes to maintain economic viability at production scales).
Reaction Time Constraints in Flow Technology
This constraint is significant, as many reactions require longer timeframes to reach completion. This is often seen as one of the main hurdles toward the more widespread adoption of flow technology. For example, a second-order reaction (1 M) in water with an activation enthalpy of 9.8 kcal mol-1 and an activation entropy of -0.0456 kcal mol-1 requires 5 days to reach completion (>99% conversion) at room temperature.
At reflux (100 °C), the reaction rate increases 35-fold, yet it still takes over 3 hours to reach completion, making it unsuitable for flow technology. Batch processes typically operate within the solvent’s boiling point. This drastically limits the reaction temperature window and requires solvent changes to achieve higher temperatures, which introduces additional drawbacks. Solvent choices become restricted to boiling points, often compromising reaction compatibility, solubility, selectivity, cost, and toxicity.
“Superheated flow technology leverages the advantages of flow processes by operating above solvent boiling points to enhance reaction rates, improving productivity and safety, and aligning with sustainability goals, explains Jean-Christophe Monbaliu, head of the CiTOS Lab. Returning to our example, the same reaction under superheated conditions at 200 °C in water would see a 713-fold acceleration, potentially reaching completion within 10 minutes.” Like a wizard, superheated conditions defy common wisdom, compressing both time- and spaceframes within processes and making slow reactions amenable to flow technology.
Despite its significant benefits, accessing superheated flow conditions is complex and resource-intensive, especially for newcomers. In this Account, we provide a concise overview of superheated flow chemistry, including key concepts, reactor options, and strategic adoption methods using Design of Experiments, microwave test chemistry, kinetics data, and Quantum Mechanics. “Our goal is to guide the exploration of extended chemical spaces and accelerate organic synthesis, concludes Jean-Christophe Monbaliu. We also highlight recent examples from our lab and other leading contributors worldwide.”
Reference: “New Opportunities for Organic Synthesis with Superheated Flow Chemistry” by Pauline Bianchi and Jean-Christophe M. Monbaliu, 23 July 2024, Accounts of Chemical Research.
DOI: 10.1021/acs.accounts.4c00340
Funding: WEL Research Institute, Fonds De La Recherche Scientifique – FNRS